Dynamic instability of microtubules is regulated by force
نویسندگان
چکیده
منابع مشابه
Dynamic instability of microtubules is regulated by force
Microtubules are long filamentous protein structures that randomly alternate between periods of elongation and shortening in a process termed dynamic instability. The average time a microtubule spends in an elongation phase, known as the catastrophe time, is regulated by the biochemical machinery of the cell throughout the cell cycle. In this light, observed changes in the catastrophe time near...
متن کاملMathematical Modeling of Dynamic Instability in Microtubules
Microtubules are biological polymers that have many functions in cells, such as support and structure in the cytoskeleton, providing avenues and mechanisms for intracellular transportation, and separating chromatids during cell division. Microtubule dynamic instability is an integral part of cell functioning, enabling microtubules to rapidly find and change spatial arrangements and interact wit...
متن کاملNote on the dynamic instability of microtubules
Note on the dynamic instability of microtubules Abstract If the dynamic instability of microtubules follows a gamma distribution then one can associate to it a Cantor set. Microtubules (MTs), the main protein polymeric filaments of the cell cy-toskeleton, are a well-defined biological system where methods in condensed matter, statistical mechanics and the theory of complex systems have been app...
متن کاملDynamic Simulation and Mechanical Properties of Microtubules
This work is conducted to obtain mechanical properties of microtubule. For this aim, interaction energy in alpha-beta, beta-alpha, alpha-alpha, and beta-beta dimers was calculated using the molecular dynamic simulation. Force-distance diagrams for these dimers were obtained using the relation between potential energy and force. Afterwards, instead of each tubulin, one sphere with 55 KDa weight ...
متن کاملVascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms
Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200301147